GIFRER GLYCERIN SUPPOSITORY Adult suppositories 10 sachets

Glycerol ........................................................................................................................................................................1,98 g

For a suppository of 3,30 g

• Symptomatic treatment of low constipation, particularly due to rectal dyschezia.
• Preparation for endoscopic examinations of the rectum.

• Treatment of lower constipation:
  1 to 2 suppositories per day to obtain one bowel movement per day.
• Preparation for endoscopic examinations of the rectum:
  1 suppository 5 to 30 minutes before the time chosen for evacuation.

History of hypersensitivity to the active substance or to any of the excipients.

Obstructive colopathy, given the laxative effect of the medicinal product.

Abdominal pain syndrome of undetermined and inflammatory cause (ulcerative colitis, Crohn's disease).

Warnings special

Prolonged use is not recommended.

Drug treatment of constipation is only an adjunct to dietary and hygienic treatment:

• enrichment of the diet with vegetable fibres and fluids,
• Advice on physical activity and rehabilitation of evacuation.

Precautions for use

It is preferable not to use this medicinal product in cases of colonic disease, hemorrhoidal flares, anal fissures, or hemorrhagic proctocolitis.

The data available to date do not suggest the existence of clinically significant interactions.

Use with caution in pregnant or breastfeeding women, due to a lack of usable clinical data.

Prolonged use may give rise to anal burning sensations and, exceptionally, congestive reactions.

Reporting of suspected adverse reactions

Reporting suspected adverse effects after authorisation of the medicinal product is important. It allows continuous monitoring of the benefit/risk balance of the medicinal product. Health professionals should report any suspected adverse effect via the national reporting system: National Agency for the Safety of Medicines and Health Products (ANSM) and the network of Regional Pharmacovigilance Centres. Website: www.ansm.sante.fr.

No cases of overdose with glycerol suppositories have been reported. However, in case of prolonged use, there is an increased risk of proctitis and diarrhoea.

Treatment: discontinue treatment or reduce the dose.

Pharmacotherapeutic class: LAXATIVE FOR RECTAL USE.

OTHER LAXATIVES (A: Alimentary tract and metabolism) – ATC code: A06AX 01

Glycerin suppositories cause rapid evacuation of the rectosigmoid by triggering the defecation reflex. Defecation occurs within 5 to 30 minutes after administration.

Glycerol stimulates peristaltic movements and decreases water reabsorption through its osmotic and hygroscopic properties. It also has a local irritant effect that contributes to the reflex defecation.

3 years

Store at a temperature not exceeding 25°C.

No special requirements.